Temperature Sensitivity

A client had a natural product and was concerned to know if the strength of the tablets and overall manufacturability would change on scale up as the production press heated up.

It is well know that when production presses are used, friction causes the temperature to increase significantly.

Temperatures in excess of 50°C are common. Merlin carried out compression tests at dwells times encountered in production to mimic the manufacturing process.

The temperature of the die was changed using a heated die, controlled to precise temperatures at intervals between 20°C and 60°C. The testing required only ~ 50g of product.

The results showed how the properties of the tablets changed with changes in press temperature and allowed the company to take this into consideration during scale-up and commercialisation.

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