The problems were linked to poor compression strength during production, and we were asked to investigate the tablet compression at slow and fast speeds, using Heckel, tabletability, compressibility and compactibility testing. Due to the materials already being a commercial product, there is little room for change to the formulation apart from process settings.
We had already been told that the client's tablets had difficulty consistently achieving the target disintegration times and they were also friable and prone to capping. The client had run internal trials, and the problem required further information.
Following our investigation, we were able to give further insights into the cause of the manufacturing issues and suggest improvements which could be made within the limitations of the manufacturing licence.