As a production press runs, the temperature of the press increases through friction. We can simulate the temperatures of a production press using our compaction simulator. Materials with a low melting point are most at risk.
We can simulate the temperature of a production press.
As a production press runs, the temperature of the press increases through friction. We can simulate the temperatures of a production press using our compaction simulator. Materials with a low melting point are most at risk.
Merlin has a temperature controlled die that can simulate the higher operating temperatures which occur on a real full scale production press (-10°C up to 70°C) to assess the impact of temperature on the behaviour of the formulation during compaction and ejection.
The effect of scale up temperatures can be predicted using small scale tests on a few grams of material. Knowing what to expect on scale up will avoid any nasty surprises.
The scale-up of tablet manufacturing can be difficult. The issues seen are the effects of compression speed and the build up of heat due to the length of the compaction, as it cannot be determined on a smaller scale.
During the compaction of powder, temperatures rise in the compressed powder which can affect the physiochemical properties.
Have you also considered ejection force measurement and punch adhesion to see whether temperature effects sticking during compression? For more information, visit these pages or call 01509860222.
Or you can call us on +44(0)1509 860 222
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