When it comes to tablets, hardness testing measures the structural integrity and breaking point of a tablet during transportation and manufacturing.
Tablet hardness testing is used within the pharmaceutical industry to test the diametrial crushing strength and structural integrity of a tablet. It is not true hardness; which usually refers to a surface phenomenon; but the term used in pharmaceuticals for crushing strength under tensile failure.
Tablet hardness can serve as a guide for product development and as a quality-control specification. The tablets should not be too hard or too soft, as a hard tablet could prevent the dissolution of the tablet, which is needed for an accurate dosage. However, if the tablet is too soft it could lead to quick disintegration, and it can easily chip or break during packaging and transport.
Factors that could affect the hardness of tablets are:
To investigate the hardness of a tablet, we use a Holland C50.
We test the hardness by placing the tablet between two jaws. One of the jaws then moves towards the tablet pushing it against the fixed jaw until the tablet breaks. The load at which the tablet fails across the diameter is then recorded.
For more information about hardness testing, get in touch today by completing our online contact form here, by emailing email@example.com, or by calling +44(0)1509 860 222.
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