Scientific Papers

The purpose of this work is to demonstrate that compaction simulation can be used to calibrate a terahertz analyzer on a multi-component tablet system for rapid, non-destructive in process monitoring of roller compaction and tableting processes.

A formulation of ibuprofen 200 mg was evaluated using Quality by Design principles to:

• Study the effect of Twin Screw Wet Granulation (TSWG) factors on granule quality;

• Characterise the final compressed tablet.

The aim was to develop a simple method to quantify sticking risk using a minimal amount of material, which could be used early in development. A Compaction Simulator and a novel instrumented punch were used to characterise the sticking behaviour of 5 formulations, some of which were known to adhere to tablet punches during compression.