To find out more information about the research Merlin has completed click on the links below.
Download our latest scientific paper.
To find out more information about the research Merlin has completed click on the links below.
The purpose of this work is to demonstrate that compaction simulation can be used to calibrate a terahertz analyzer on a multi-component tablet system for rapid, non-destructive in process monitoring of roller compaction and tableting processes.
A formulation of ibuprofen 200 mg was evaluated using Quality by Design principles to:
• Study the effect of Twin Screw Wet Granulation (TSWG) factors on granule quality;
• Characterise the final compressed tablet.
The aim was to develop a simple method to quantify sticking risk using a minimal amount of material, which could be used early in development. A Compaction Simulator and a novel instrumented punch were used to characterise the sticking behaviour of 5 formulations, some of which were known to adhere to tablet punches during compression.
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