Yield pressures can be used from Heckel profiles to assess the time-dependant deformation properties of particles during compression by comparing yield pressure values derived under compression at different punch speeds (Fast and Slow). Contact us for more information on Strain Rate Sensitivity.
Indication of Scale-Up Risk
Strain Rate Sensitivity (SRS) gives an indication of the risk of scale-up on the material characterisation of Active Pharmaceutical Ingredients. Categorising the API according to yield pressure (Slow) and SRS allows the API to be compared against the properties of other materials.
For some materials, the deformation characteristics change with rate of applied force. This can be estimated by calculating the Strain Rate Sensitivity. The yield pressure at high speed compression is compared to that at slow speed using an equation.
How Can We Help?
The Merlin team can complete a heckel test on your test materials to calculate the Strain Rate Sensitivity. During a Heckel test the test material is compressed under high forces using a compaction simulator. Force versus relative density measurements are used to determine the theoretical yield pressure of the material using the heckel equation. The Strain Rate Sensitivity is then calculated.
Have you also considered API and material characterisation? For more information, visit these pages or call 01509860222.
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